Ectopic DNMT3B expression delays leukemogenesis

Ectopic expression in Drosophila.

Ectopic expression of tenascin-C.

We read, with much interest, the recent Research Article by Järvinen et al. (Järvinen et al., 2003), in which the authors show that, after removing the cast from an immobilized rat hind leg, within 8 weeks tenascin-C (TN-C) expression is increased in tendon and the myotendinous junction, but there is no de novo appearance of TN-C in skeletal muscle connective tissue. The authors extensively cri...

Efficient ectopic gene expression targeting chick mesoderm.

The chick model has been instrumental in illuminating genes that regulate early vertebrate development and pattern formation. Targeted ectopic gene expression is critical to dissect further the complicated gene interactions that are involved. In an effort to develop a consistent method to ectopically introduce and focally express genes in chick mesoderm, we evaluated and optimized several gene ...

Ectopic Expression of DNA Encoding IFN-

Preleukemia in experimental leukemogenesis.

The long latent period characteristic for both spontaneous and induced murine leukemias may reflect multiple steps in the leukemogenic process. The induction of pre leukemia represents the initial phase in leukemogenesis. A sequence of further events (that could differ qualitatively from the initiating factor) is often required for the completion of the neoplastic transformation. The presence o...